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mesotheliomaaa.com All About Mesothelioma What is mesothelioma? October 3rd, 2010 Mesothelioma, more precisely malignant mesothelioma, is a rare form of cancer that develops from the protective lining that covers many of the body?s internal organs, the mesothelium. It is usually caused by exposure to asbestos.Its most common site is the pleura (outer lining of the lungs and internal chest wall), but it may also occur in the peritoneum (the lining of the abdominal cavity), the heart, the